Electrochemical determination of aripiprazole based on aluminium oxide nanoparticles modified carbon paste electrode

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Öztürk F., Yüksel E., Erden P. E., Kiliç E.

Turkish Journal of Chemistry, cilt.47, sa.1, ss.126-136, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.55730/1300-0527.3523
  • Dergi Adı: Turkish Journal of Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.126-136
  • Anahtar Kelimeler: aluminium oxide nanoparticles, Aripiprazole, biological fluid, carbon paste electrode, pharmaceutical formulation, square wave voltammetry
  • Ankara Hacı Bayram Veli Üniversitesi Adresli: Evet

Özet

The electrochemical oxidation of aripiprazole was explored at a carbon paste electrode modified with aluminium oxide nanoparticles by cyclic voltammetry and square-wave anodic adsorptive stripping voltammetry. Experimental parameters such as carbon paste composition, scan rate, buffer pH, accumulation time, and accumulation potential were optimized in order to obtain high analytical performance. The incorporation of aluminium oxide nanoparticles into the carbon paste matrix enhanced the effective surface area of the carbon paste electrode and improved the sensitivity. On the aluminium oxide nanoparticles modified carbon paste electrode, aripiprazole exhibited an irreversible anodic peak at +1.17 V in pH 1.8 BR buffer solution. Under optimum conditions, the peak current exhibited a linear dependence with aripiprazole concentration between 0.03 and 8.0 µM with a detection limit of 0.006 μM. The analytical applicability of the voltammetric method was evaluated by quantification of ARP in human serum samples and pharmaceutical formulations.