In this study, potential of the alginate based electrospun nanofibrous mats as wound dressings was investigated macroscopically in vivo experiments. 2/1 (v/v) %9 PVA / %1 NaAlg nanofibrous mats were produced by electrospinning method. in order to improve water resistance of the electrospun mats, the cross-linking was performed. SEM analyses, thickness and air permeability tests were applied for the nanofibrous mats produced as wound dressing and Suprasorb-A commercial alginate wound dressing. in vivo experiments, the healing performances of the wounds dressed by using cotton gauze, Bactigras, Suprasorb-A and the electrospun PVA/NaAlg nanofibrous mat were macroscopically evaluated and compared. The wound healing potential of the electrospun mat was better than that of cotton gauze including a drug and looked like antibacterial Bactigras. The results indicated that the electrospun PVA/NaAlg nanofibrous mat as wound dressing provided a good means for wound healing.