A New Hope in the Treatment of Intraventricular Haemorrhage in Preterm Infants: Mesenchymal Stem Cells

Bozkaya D., Ceran B., Ozmen E., Okman E., Dizdar E. A., Suna S. O., ...More

TURKISH NEUROSURGERY, vol.32, no.2, pp.344-346, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.5137/1019-5149.jtn.34850-21.2
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.344-346
  • Keywords: Intraventricular haemorrhage, Mesenchymal stem cells, Premature infant, Treatment, OUTCOMES
  • Ankara Haci Bayram Veli University Affiliated: Yes


To date, there has been no effective treatment to prevent brain damage in premature infants or to prevent the development of post-hemorrhagic hydrocephalus (PHH) after severe intraventricular hemorrhage (IVH). Therefore, new, safe and effective treatment methods need to be developed to improve the prognosis of IVH, for which morbidity and mortality rates are high. Recent studies have shown that the strong immunomodulatory properties of mesenchymal stem cells (MSCs) have an anti-inflammatory effect after IVH, inhibiting the development of PHH and decreasing apoptosis and gliosis, thus improving the self-renewal ability of neuronal tissues. For this reason, MSCs transplantation after IVH is a promising treatment method. In this article, we present a case of gradeIII IVH who recovered after MSCs transplantation.