Reactions of aminopyrimidine derivatives with chloroacetyl and isophthaloyl chlorides
Heteroatom Chemistry, cilt.29, sa.4, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 4
- Basım Tarihi: 2018
- Doi Numarası: 10.1002/hc.21458
- Dergi Adı: Heteroatom Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: aminopyrimidine, isophthalimide, Mizoroki-Heck coupling reaction, pyrimidin-[1(2H)-yl]acetamide, synthesis, MIZOROKI-HECK, PYRIMIDINE, ANALOGS
- Ankara Hacı Bayram Veli Üniversitesi Adresli: Hayır
Özet
© 2018 Wiley Periodicals, Inc.1-Aminopyrimidine-2-one derivatives (1a-c) were prepared in two steps from furan-2,3-diones and semicarbazones in toluene/benzene. Pyrimidin-[1(2H)-yl] acetamide derivatives and isophthalimide derivatives were synthesized from the nucleophilic acyl substitution reactions of compounds 1a-c with chloroacetyl chloride. The structures of compounds 2a-f were verified by IR, 1H NMR, 13C NMR and elemental analyses. The obtained final organic compounds were tested as catalysts in the Mizoroki-Heck coupling reaction. They mostly exhibited very high catalytic activity results for the coupling reaction of styrene with different aryl bromide derivatives.