Encapsulation of Low Metronidazole Dose in Poly (D, L-lactide-co-glycolide) (PLGA) Nanoparticies Improves Giardia intestinalis Treatment

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Madbouly N. A., Nashee H., Elgendy A. A., Rabee I., El Amir A.

INFECTION AND CHEMOTHERAPY, vol.52, no.4, pp.550-561, 2020 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.3947/ic.2020.52.4.550
  • Journal Name: INFECTION AND CHEMOTHERAPY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.550-561
  • Keywords: Giardia intestinalis, Metronidazole, PLGA nanoparticles, ANTIBODY-RESPONSE, DRUG-RELEASE, LAMBLIA
  • Ankara Haci Bayram Veli University Affiliated: No

Abstract

Background: The present study was designed to investigate the antigiardial efficacy of low metronidazole dose loaded-D, L-lactide-co-glycolide (LMD-PLGA) nanoparticles (NPs) and to compare it with the standard high dose of metronidazole either free (HMD) or loaded on PLGA (HMD-PLGA).