Encapsulation of Low Metronidazole Dose in Poly (D, L-lactide-co-glycolide) (PLGA) Nanoparticies Improves Giardia intestinalis Treatment

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Madbouly N. A., Nashee H., Elgendy A. A., Rabee I., El Amir A.

INFECTION AND CHEMOTHERAPY, cilt.52, sa.4, ss.550-561, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3947/ic.2020.52.4.550
  • Dergi Adı: INFECTION AND CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.550-561
  • Anahtar Kelimeler: Giardia intestinalis, Metronidazole, PLGA nanoparticles, ANTIBODY-RESPONSE, DRUG-RELEASE, LAMBLIA
  • Ankara Hacı Bayram Veli Üniversitesi Adresli: Hayır

Özet

Background: The present study was designed to investigate the antigiardial efficacy of low metronidazole dose loaded-D, L-lactide-co-glycolide (LMD-PLGA) nanoparticles (NPs) and to compare it with the standard high dose of metronidazole either free (HMD) or loaded on PLGA (HMD-PLGA).