Association of BMPR-1B Gene 3 '-UTR Region Polymorphism with Litter Size in Tibetan Sheep

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Jia J., Xie D., Zhang Y., Zhang H., Zhang L., Hou S., ...More

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.27, no.3, pp.285-289, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.9775/kvfd.2020.25064
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.285-289
  • Keywords: Tibetan sheep, BMPR-1B gene, 3 '-UTR region, Polymorphism, Litter size, EXPRESSION
  • Ankara Haci Bayram Veli University Affiliated: No


Bone Morphogenetic Protein Receptor-1B (BMPR-1B) is considered as the primary gene in sheep for follicular development and litter size trait. It has been defined as the most major candidate gene for genetic markers of sheep reproductive performance. In our study, polymorphisms in the BMPR-1B gene 3'-UTR region were investigated in 363 Tibetan sheep (119 Plateau-type Tibetan sheep, 141 Valley-type Tibetan sheep, and 103 Oula-type Tibetan sheep) by DNA sequencing analysis. Two single nucleotide polymorphisms (SNPs) were identified, which were G1339A and A1354G. The frequencies of SNPs were in Hardy-Weinberg equilibrium (Chi-square test, P>0.05). AA and AG genotypes were found in the A1354G variant of the 3'UTR region, that AA and A were the preponderant genotype and allele, respectively. The chi 2 independence test analyses indicated that the A1354G variant of BMPR-1B gene 3'UTR region polymorphisms was significantly correlated with litter size in all-types Tibetan sheep (P<0.05). These results demonstrate that the BMPR-1B gene 3'-UTR region might be a potential candidate gene for marker-assisted selection (MAS).