Temperature-responsive hydrogels based on linear HPC and crosslinked P(NTBA-co-AAm) were prepared by the semi-IPN technique. The structure of these semi-IPN hydrogels was investigated by FT-IR spectroscopy. An increase in normalized band ratios (A2980/A1665) was observed with increasing HPC content in the initial mixture. The swelling kinetics and water transport mechanism of these semi-IPN hydrogels were examined and their temperature responsive behaviors were also investigated by measuring equilibrium swelling ratios and pulsatile swelling experiments. The results showed that these semi-IPN hydrogels underwent a volume phase transition between 18 and 22°C irrespective of the amounts of MBAAm and HPC. However, below the volume phase transition temperature, their equilibrium swelling ratios were affected by the amount of MBAAm and HPC. The pulsatile swelling experiments indicated that the lower the MBAAm and the higher HPC contents in semi-IPN hydrogels the faster the response rate temperature change. © 2006 WILEY-VCH Verlag GmbH & Co. KGaA.