Doping agent naphazoline hydrochloride: Development of simple and fast voltammetric method for its determination in human serum

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Çetinkol T., Öztürk F., Erden P. E.

Journal of the Turkish Chemical Society, Section A: Chemistry, vol.6, no.1, pp.79-88, 2019 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.18596/jotcsa.450793
  • Journal Name: Journal of the Turkish Chemical Society, Section A: Chemistry
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.79-88
  • Keywords: Aluminum oxide nanoparticles, Doping agent, Electrochemical techniques, Human serum, Naphazoline
  • Ankara Haci Bayram Veli University Affiliated: No


© 2019, Turkish Chemical Society. All rights reserved.Electrochemical behavior of naphazoline hydrochloride on a carbon paste electrode that was modified with aluminium oxide nanoparticles (Al2O3NPs) was investigated in a Britton-Robinson (BR) buffer (pH 7.0) using various voltammetric techniques. The results support the presence of an irreversible and diffusion-controlled electrochemical oxidation signal of naphazoline hydrochloride which is approximately at 0.9 V vs. Ag/AgCl. A selective, accurate, and simple square-wave anodic adsorptive stripping voltammetric method was proposed for naphazoline hydrochloride detection. The linear response was within the range of 5.0 × 10-8-3.0 × 10-5 mol L-1 with a detection limit of 2.6 × 10-9 mol L-1 (0.642 μg L-1). In addition, the proposed method was also utilized for naphazoline hydrochloride determination in human serum sample.