Synthesis and antimicrobial evaluation of novel heterocyclic compounds containing thiosemicarbazone
Main Group Chemistry, cilt.25, sa.2, ss.125-133, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.1177/10241221251380069
- Dergi Adı: Main Group Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
- Sayfa Sayıları: ss.125-133
- Anahtar Kelimeler: antimicrobial activity, condensation reaction, heterocyclic compounds, thiosemicarbazide
- Ankara Hacı Bayram Veli Üniversitesi Adresli: Evet
Özet
Herein, six novel heterocyclic compounds containing thiosemicarbazone were obtained by the condensation reaction of thiazole with thiosemicarbazide and benzaldehyde derivatives. The structures of newly obtained thiosemicarbazone-based heterocyclic compounds were investigated by spectroscopic methods (element analysis, infrared spectra (IR), proton nuclear magnetic resonance (1H-NMR), high resolution mass spectrometry (HRMS), scanning electron microscopy and energy dispersive X-ray (SEM-EDX). The antimicrobial efficiency of the obtained thiosemicarbazone-based heterocyclic compounds was screened in vitro against some pathogenic bacteria and yeast as potential medicinal agents. New heterocyclic compounds containing thiosemicarbazone were determined to be effective in varying degrees at inhibiting the activity of the tested disease-causing pathogenic strains. The heterocyclic compounds were found to show high or moderate antimicrobial activity. It was found that the synthesized heterocyclic compounds showed high or moderate antimicrobial activity.