Facile synthesis of heteroaryl substituted γ-lactams from nitrovinyl arenes

Çinar S., ÜNALEROĞLU C.

Turkish Journal of Chemistry, vol.42, no.1, pp.29-35, 2018 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.3906/kim-1705-25
  • Journal Name: Turkish Journal of Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.29-35
  • Keywords: Aliphatic nitroalkanes, Michael addition, Nitrovinyl arenes, Γ-lactam
  • Ankara Haci Bayram Veli University Affiliated: No

Abstract

© TÜBITAK.Aliphatic nitroalkanes with different functional groups were synthesized from the Michael addition reactions of active methylene compounds 2 and nitrovinyl arenes 1 in high yields. The synthesized Michael adducts were subjected to intramolecular cyclization to give heteroaryl substituted γ-lactams in good to high yields under mild reaction conditions.