Facile synthesis of heteroaryl substituted γ-lactams from nitrovinyl arenes

Çinar S., ÜNALEROĞLU C.

Turkish Journal of Chemistry, cilt.42, sa.1, ss.29-35, 2018 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3906/kim-1705-25
  • Dergi Adı: Turkish Journal of Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.29-35
  • Anahtar Kelimeler: Aliphatic nitroalkanes, Michael addition, Nitrovinyl arenes, Γ-lactam
  • Ankara Hacı Bayram Veli Üniversitesi Adresli: Hayır

Özet

© TÜBITAK.Aliphatic nitroalkanes with different functional groups were synthesized from the Michael addition reactions of active methylene compounds 2 and nitrovinyl arenes 1 in high yields. The synthesized Michael adducts were subjected to intramolecular cyclization to give heteroaryl substituted γ-lactams in good to high yields under mild reaction conditions.